Advanced lymphoma treatment technology under development at Iran's Royan Institute
Iran's Royan Institute is developing an advanced CAR T-cell gene therapy for patients with treatment-resistant lymphoma, aiming to introduce one of the world's most sophisticated cell-based cancer therapies, a senior official said.
Ansiyeh Hajizadeh, director of the Advanced Cell Products Technology Development Center at the Royan Institute, said the project is among the institute's latest efforts in advanced therapy medicinal products (ATMPs).
"One of the treatment categories currently recognized worldwide as advanced therapy medicinal products is gene therapy, which has attracted significant global investment in recent years," Hajizadeh said.
She noted that Royan is currently developing a gene therapy product based on CAR T-cell technology, a personalized cell therapy already used in several countries to treat certain blood cancers.
"We are currently conducting research and development on a gene therapy product that is, in fact, a cell therapy similar to CAR T-cell products available internationally," she said.
According to Hajizadeh, more than six CAR T-cell products have already received regulatory approvals in both the United States and Europe for clinical use.
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She explained that the therapy is designed for patients with lymphoma, a type of blood cancer that has become resistant to conventional treatments.
Describing the treatment process, Hajizadeh said doctors first collect blood from the patient and isolate T lymphocytes, which are then genetically engineered to recognize and attack cancer cells.
"The patient's T cells are equipped with a gene that enables them to identify the tumor. They are then expanded and infused back into the patient's body, where they can target and destroy the cancer," she said.
The therapy offers new hope for patients who have exhausted standard treatment options, she added.
"Patients who have undergone various treatments without successfully overcoming their cancer may benefit from this gene therapy. Their own cells are genetically modified to gain the ability to fight the disease before being returned to the body," Hajizadeh said.
She described the therapy as one of the most advanced high-tech medical products currently under development at the Royan Institute.
"This is a highly advanced, high-tech product being developed by researchers at the Royan Institute. We hope to successfully complete the remaining stages of development and obtain the necessary regulatory approvals in the near future," she said.
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