Manchester City's winning streak has been snapped after 21 games, following a 2-nil loss against their arch rivals Manchester United at the Etihad Stadium.
The visitors took a shocking lead after Bruno Fernandes converted from the spot, just two minutes after kick-off, following a reckless foul by Gabriel Jesus.
The Red Devils put the match beyond doubt before the hour mark, when Luke Shaw lashed the ball in from a pass by Marcus Rashford.
With the victory of the 184th Manchester Derby, United reclaimed the second spot with 54 points, but are still 11 points behind the Sky Blues, who have collected 65 points.