Thousands took to streets in Managua to demand an end to Nicaraguan President Daniel Ortega's government.
Protesters carried Nicaraguan flags and signs calling for the ruling party to step down.
"It is a mafia government. They have taken over all institutions and they have ransomed us. We have to free ourselves. People already do not accept this government. There is civil disobedience and a civic protest," said one of the demonstrators.
Anti-government protests have paralyzed Nicaragua for nearly three months. According to the Inter-American Commission on Human Rights, 264 have been killed since the latest wave of unrest began in late April.
Ortega's government branded the protesters as 'vandals' and 'terrorists', claiming that they are in the pay of foreign countries.