Uber drivers blocked the main street leading from the European institutions to the center of Brussels on Thursday in anger about a court ruling which will see their activities halted from Friday evening.
The court ruled that a 2015 ban on private individuals offering taxi services also applies to professional drivers and the company said it would cease operations in Brussels from 1800 local time (1700GMT) Friday.
Uber said the decision by the Brussels Appeals Court on Wednesday will affect around 2,000 drivers, and it urged the Belgian government to quickly change taxi service laws.
"The situation is catastrophic. We find ourselves without jobs, with no income, we've all got families and bills to pay," said driver Shah Sayed, blocking the rue de la Loi on Thursday.