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OK, so marijuana is now legal in Washington state. But does that mean it's good for you?

"Daily use increases the risk of becoming dependent," says Roger Roffman, a professor emeritus at the University of Washington's School of Social Work. He supported Initiative 502, which called for the legalization of a small amount of marijuana for adults 21 and older in Washington.

Roffman says there are positive effects of marijuana use: It can help people relax and interact with others. It also can enhance some sensory experiences, like listening to music. And consumption for medical purposes can reduce symptoms of disease and treatments of disease, he says.

But dependence can cause impairment or distress, and effects that interfere with other areas of life, he says. "It's fairly common for people who are using marijuana regularly to complain that their ability to think clearly is impaired -- to remember, to organize their thoughts, to follow through with multitasking."

TLC, the active ingredient in marijuana "hijacks and corrupts" the natural process of endocannabinoids, a key family of chemicals that help guide the brain in proper maturation, says Ruben Baler, a neuroscientist with the National Institute on Drug Abuse (NIDA). These chemicals "play key roles in memory formation, learning, decision-making," says Baler.

Not everyone who uses marijuana regularly experiences problems with thinking and memory, says Roffman. But researchers have not been able to predict which users will which won't.

"One of the main contributors to worse outcomes (of marijuana use) is the age at which you start," says Baler. "So we are particularly worried about young people who are using the drug."

The concern, especially for young people, "is that you're performing sub-optimally during those years when you should be working at peak levels of performance," he says. And with day-after-day use, the drug has a cumulative effect on achievement. Studies show that when marijuana is used chronically, "people achieve lower in academics, job performance and life satisfaction," says Baler. "It's difficult to understand why kids working so hard on their education, would engage in an act that would lower their chance of success."

And yes, marijuana is addictive, adds Baler. Approximately 1 in 5 people will become addicted. They can become quite ill if they try to quit. "There are many people who go into treatment to get over an addiction to marijuana."

Washington and Colorado became the first states to vote to decriminalize the possession of an ounce or less of marijuana by adults older than 21. Colorado's law is scheduled to take effect by Jan. 5.

More research is needed on how marijuana affects people of different ages and backgrounds, Roffman says. "There is evidence of genetic vulnerability to dependence. It is still at an early stage of being studied."

Certain health conditions also put people at higher risk of problems. For example, people with cardiovascular disease will be at an increased risk of a heart attack, he says.

More than 29 million Americans ages 12 and older -- 11.5% -- reported using marijuana within the past year, according to NIDA numbers for 2010. That's a significant increase over numbers reported each year from 2002 to 2008.

Here's what's the institute says is known about the effects of the drug, a shredded green and brown mix of flowers, stems, seeds and leaves derived from the hemp plant Cannabis sativa.

NIDA says that marijuana's main psychoactive ingredient, tetrahydrocannabinol (THC), binds to cannabinoid (CB) receptors, widely distributed throughout the nervous system and other parts of the body. In the brain, CB receptors are found in high concentrations in areas that influence pleasure, memory, thought, concentration, sensory and time perception, appetite, pain, and movement coordination.

That's why marijuana can have wide-ranging effects, including:

-- Impaired short-term memory. Marijuana use can make it hard to learn and retain information, particularly complex tasks.

-- Slowed reaction time and impaired motor coordination. It can throw off athletic performance, impair driving skills, and increase risk of injuries.

-- Altered judgment and decision making. Experts say this can contribute to high-risk sexual behaviors that could lead to the spread of sexually transmitted diseases

-- Increased heart rate. It can jump by 20% to 100%, which may increase the risk of heart attack, especially in otherwise vulnerable individuals.

-- Altered mood. In some, marijuana can induce euphoria or calmness; in high doses it can cause anxiety and paranoia.

The agency says long-term marijuana abuse can lead to:

-- Addiction.

-- Poorer educational outcomes, poorer job performance, and diminished life satisfaction.

-- Respiratory problems (chronic cough, bronchitis).

-- Risk of psychosis in vulnerable individuals.

-- Cognitive impairment persisting beyond the time of intoxication.

AN/SM