The Independent Flight Attendants' Organization (UFO) has demanded a five-percent pay increase and guarantees that jobs will not be outsourced to temporary workers. However, Lufthansa has offered a pay increase of 3.5 percent in exchange for longer hours.
In 2009, a similar strike by cabin crew cost Lufthansa tens of millions of euros.
The airline normally operates about 1,800 flights a day around the world.
Lufthansa has said that the upcoming strike scheduled to be held on Friday by its cabin staff over pay and conditions would cancel two-thirds of flights in one day.
Lufthansa cabin crew will strike throughout Germany on Friday for 24 hours. The strike would take place at Frankfurt, Berlin, Hamburg, Munich, Dusseldorf, and Stuttgart airports.
According to an airline spokesman, 600 of Friday's 1,800 Lufthansa flights would be conducted by "partner airlines" not affected by the strike.
On Tuesday, cabin staff walked out at Frankfurt, Munich, and Berlin airports, forcing the German airline to cancel hundreds of flights.