Press TV reports.
Press TV correspondent in Mogadishu says the unmanned aircraft went down near El-Bur town early Tuesday and caused "a massive explosion."
The US military uses drones in several Muslim countries including Yemen, Somalia and Pakistan.
Washington claims the airstrikes target militants, though they have mostly resulted in civilian casualties.
El Bur has been serving as a key command and control base for al-Shabab fighters in the region for the past three years.
Residents of El-Bur told Press TV that hundreds of al-Shabab fighters left the town March 24.
Somalia has not had a functioning government since 1991, when warlords overthrew former dictator Mohamed Siad Barre.
The weak Western-backed transitional government in Mogadishu has been battling al-Shabab fighters for the past five years and is propped up by a 12,000-strong African Union force from Uganda, Burundi, and Djibouti.
An American assassination drone has crashed in Somalia’s central province of Galgaduud, causing a "massive explosion,"