Roma have also booked their spot in the last 16 of the Europa League, with a 4-1 aggregate victory over Villarreal, despite suffering a 1-0 home defeat in the second leg by the Spanish club.
Former Tottenham striker Rafael Santos Borre, who was making his first appearance after 6 months being out with a knee injury, availed himself of a loose ball in the box to give Villarreal the lead with a clinical finish after 15 minutes.
But the deficit was too great for the Spanish Club to close, as they had to be only satisfied claiming their first ever win in Italy, to recover some pride after a 4-0 thrashing home defeat in the first leg.